Patents
Anderson, D.G.; Gupta, A.; Reed, K.P.; Weissleder, R.; Garris, C.; Das, R.; US Patent App. 63/746,840, Filed January 2025, “mRNA-based Myeloid Cell Stimulation Enhances Therapeutic Efficacy.”
Publications
† denotes co-first authors
27. Gupta, A.†; Das, R.†; Reed, K.†; Jeon, T.; Nguyen Q.T.C.; Rudra, A; Ge, X.; Trongjit, S.; Vanrobaeys, Y.S.; Langer, R.; Weissleder, R.; Garris, C.; and Anderson D. G. Immune-remodeling mRNAs expressing IRF8 or NIK generate durable antitumor immunity in multiple cancer models. Nature Biotechnology. 2026.
26. Deutsch-W., R.; Schleyer, K.; Das, R.; Carrothers, J.; Kohler, R.; Vinegoni, C.; Weissleder, R. FAP-targeted Fluorescent imaging agents to study cancer-associated fibroblasts in vivo. Bioconjugate Chem.2025, 36, 44−53.
25. Das, R.; Ge, X.; Fei, F.; Weissleder, R.; Garris, C. S. Lipid Nanoparticle-mRNA Engineered DC Adoptive Cell Therapy Enhances Cancer Immune Response. Small Methods. 2024, 9, 1-9.
24. Das, R.; Halabi, E.A.; Fredrich, I.R.; Oh, J.; Peterson, H.M.; Ge, X.; Scott, E.; Kohler, R.; Garris, C.S.; Weissleder, R. Hybrid LNP Prime Dendritic Cells for Nucleotide Delivery. Advanced Science. 2023, 10, 1-10.
23. Das, R.; Hardie, J.; Joshi, B.P.; Zhang, X.; Gupta, A; Luther, D.C.; Fedeli, S.; Farkas, E. M.; Rotello, V. M. Macrophage-Encapsulated Bioorthogonal Nanozymes for Targeting Cancer Cells, JACS Au. 2022, 2, 1679–1685.
22. Das, R.; Zeng, W.; Asci, C.; Del-Rio-Ruiz, R.; Sonkusale, S. Recent Progress in Electrospun Nanomaterials for Wearables, APL Bioeng. 2022, 6, 021505.
21. Das, R.; Sadeqi, A.; Browne, C. A.; Lucki, I.; Sonkusale, S. Ultra Flexible Macroporous Microneedles for Sustained Delivery of (2R,6R)-Hydroxynorketamine, Solid-State Sensors, Actuators, and Microsystems, 2022, 107, 431.
20. Gupta, A.†; Das, R.†; Makabenta, J. M. V.; Gupta, A.; Zhang, X.; Jeon, T.; Huang, R.; Liu, Y.; Gopalakrishnan, S.; Mil. n, R-C.; Rotello, V. M. RBC-mediated delivery of bioorthogonal nanozymes for selective targeting of bacterial infections, Materials Horizons.2021, 8, 3424-3431.
19. Li, J.; Røise, J. J.; He, M.; Das, R.; Murthy, N. Non-Viral Strategies for Delivering Genome Editing Enzymes. Adv. Drug Deliv. Rev. 2021, 168, 99–117.
18. Espinoza, E. M.; Røise, J. J.; Li, I.-C.; Das, R.; Murthy, N. Advances in Imaging Reactive Oxygen Species. J. Nucl. Med. 2021, 62, 457 – 461.
17. Gupta, A.; Makabenta, J. M. V.; Schlüter, F.; Landis, R. F.; Das, R.; Cuppels, M.; Rotello, V. M. Functionalized Polymers Enhance Permeability of Antibiotics in Gram-Negative MDR Bacteria and Biofilms for Synergistic Antimicrobial Therapy. Adv. Ther. 2020, 3, 2002-2010.
16. Das, R.; Landis, R.F.; Yesilbag Tonga, G.; Cao-milán, R.; Luther, D. C.; Rotello, V. M. Control of Intra- versus Extracellular Bioorthogonal Catalysis using Surface Engineered Nanozymes, ACS Nano.2019, 13, 229-235.
15. Lee, Y. -W.; Mout, R.; Luther, D. C.; Liu, Y.; Castellanos‐García, L.; Burnside, A. S.; Ray, M.; Tonga, G. Y.; Hardie, J.; Nagaraj, H.; Das, R.; Phillips, E. L.; Tay, T.; Vachet, R. W.; Rotello, V. M. In Vivo Editing of Macrophages through Systemic Delivery of CRISPR‐Cas9‐Ribonucleoprotein‐Nanoparticle Nanoassemblies. Adv. Ther. 2019, 2, 190041-190048.
14. Gupta, A.†; Das, R.†; Yesilbag Tonga, G.; Mizuhara, T.; Rotello, V. M. Charge-Switchable Nanozymes for Bioorthogonal Imaging of Biofilm-Associated Infections. ACS Nano. 2018, 12, 89–94.
13. Jeong, Y.; Duncan, B.; Yan, B.; Das, R.; Sahub, C.; Rotello, V. M. Solubilization of Hydrophobic Catalysts Using Nanoparticle Hosts. Small 2018, 1702198, 1–5.
12. Huma, Z.; Gupta, A.; Javed, I.; Das, R.; Hussain, S. Z.; Mumtaz, S.; Hussain, I.; Rotello, V.M. Cationic Silver Nanoclusters as Potent Antimicrobials against Multidrug-Resistant Bacteria. ACS Omega 2018, 3, 16721–16727.
11. Gupta, A.; Landis, R. F.; Li, C.-H.; Schnurr, M.; Das, R.; Lee, Y.-W.; Yazdani, M.; Liu, Y.; Kozlova, A.; Rotello, V. M. Engineered Polymer Nanoparticles with Unprecedented Antimicrobial Efficacy and Therapeutic Indices against Multidrug-Resistant Bacteria and Biofilms. J. Am. Chem. Soc. 2018, 140, 12137–12143.
10. Jiang, Y.; Hardie, J.; Liu, Y.; Ray, M.; Luo, X.; Das, R.; Landis, R. F.; Farkas, M. E.; Rotello, V. M. Nanocapsule-Mediated Cytosolic SiRNA Delivery for Anti-inflammatory Treatment. J. Control. Release 2018, 2, 235–240.
9. Gupta, A.; Saleh, N. M.; Das, R.; Landis, R. F.; Bigdeli, A.; Motamedchaboki, K.; Campos, A. R.; Pomeroy, K.; Mahmoudi, M.; Rotello, V. M. “Synergistic Antimicrobial Therapy using Nanoparticles and Antibiotics for the Treatment of Multidrug-Resistant Bacterial Infection,” Nano Futures. 2017, 1, 015004.
8. Landis, R. F.; Gupta, A.; Lee, Y.-W.; Wang, L.-S.; Golba, B.; Couillaud, B.; Ridolfo, R.; Das, R.; Rotello, V. M. Cross-Linked Polymer-Stabilized Nanocomposites for the Treatment of Bacterial Biofilms. ACS Nano 2017, 11, 946–952.
7. Cao-milán, R.; He, L. D.; Shorkey, S.; Tonga, G. Y.; Wang, L.-S.; Zhang, X.; Uddin, I.; Das, R.; Rotello, V. M. Modulating the Catalytic Activity of Enzyme-like Nanoparticles through Their Surface. Mol. Syst. Des. Eng. 2017, 2, 624–628.
6. Sasikala, S. P.; Henry, L.; Yesilbag Tonga, G.; Huang, K.; Das, R.; Giroire, B.; Marre, S.; Rotello, V. M.; Penicaud, A.; Poulin, P.; et al. High-Yield Synthesis of Aspect Ratio Controlled Graphenic Materials from Anthracite Coal in Supercritical Fluids. ACS Nano 2016, 10, 5293–5303.
5. Saha, K.; Rahimi, M.; Yazdani, M.; Kim, S. T.; Moyano, D. F.; Hou, S.; Das, R.; Mout, R.; Rezaee, F.; Mahmoudi, M.; Rotello, V. M. Regulation of Macrophage Recognition through the Interplay of Nanoparticle Surface Functionality and Protein Corona. ACS Nano 2016, 10, 4421–4430.
4. Gupta, A.; Moyano, D. F.; Parnsubsakul, A.; Papadopoulos, A.; Wang, L.-S.; Landis, R. F.; Das, R.; Rotello, V. M. Ultrastable and Biofunctionalizable Gold Nanoparticles. ACS Appl. Mater. Interfaces 2016, 8, 14096–14101.
3. Tonga, G. Y.; Jeong, Y.; Duncan, B.; Mizuhara, T.; Mout, R.; Das, R.; Kim, S. T.; Yeh, Y.-C.; Yan, B.; Hou, S.; Rotello, V. M. Supramolecular Regulation of Bioorthogonal Catalysis in Cells Using Nanoparticle-Embedded Transition Metal Catalysts. Nature Chemistry. 2015, 7, 597-603.
2. Jiang, Y.; Huo, S.; Mizuhara, T.; Das, R.; Lee, Y.-W.; Hou, S.; Moyano, D. F.; Duncan, B.; Liang, X.-J.; Rotello, V. M. The Interplay of Size and Surface Functionality on the Cellular Uptake of Sub-10 Nm Gold Nanoparticles. ACS Nano 2015, 9, 9986–9993.
1. Yesilbag Tonga, G.; Mizuhara, T.; Saha, K.; Jiang, Z.; Hou, S.; Das, R.; Rotello, V. M. Binding Studies of Cucurbit[7]Uril with Gold Nanoparticles Bearing Different Surface Functionalities. Tetrahedron Lett. 2015, 56, 3653–3657.